Long-read whole genome sequencing and comparative analysis of six strains of the human pathogen Orientia tsutsugamushi.
BackgroundOrientia tsutsugamushi is a clinically important but neglected obligate intracellular bacterial pathogen of the Rickettsiaceae family that causes the potentially life-threatening human disease scrub typhus.In contrast to the genome reduction seen in many obligate intracellular bacteria, early genetic studies of Orientia have revealed one